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-synuclein, that's a most important element of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, that is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) anxiety, propose that dysfunction in the intracellular proteinase methods, such as ubiquitin-proteasome method or lysosomal method, which removes unneeded toxic protei

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